However, the movie reveals that Sister Irene and Lorraine Warren are from the same bloodline. This was revealed when the movie explored Sister Irene's heritage, and it showed she is a descendant of Saint Lucy. She then has visions of people in Saint Lucy's bloodline, and one of those people was Lorraine Warren.
Sister Irene and Lorraine Warren are revealed to be part of the same bloodline, explaining why both characters are targeted by demons like Valak and Annabelle. The characters played by Taissa and Vera Farmiga are also related in the franchise.