Dean refers to the Impala affectionately as '"Baby." At the end of the series, it is unknown what became of the Impala although Sam might've left it to his son Dean Winchester II. The Impala, featuring its original license plates, also exists in Heaven at the same time as Sam owns the Impala on Earth.
Even in episodes where Lebanon's most famous sons aren't the main focus (see season 13's "Wayward Sisters"), Sam and Dean are never too far from the action. With that in mind, it's hardly surprising that both Jensen Ackles and Jared Padalecki feature in every single Supernatural episode.