No, there are no surefire ways to win at slot machines. These games are based on random chance, with each spin being independent of the one before it. Because it is difficult to foresee or manipulate outcomes, the best strategy is to play for fun and set a budget to avoid financial losses.
The jackpot is triggered by a specific combination of symbols on the reels. When you pull the lever or push the button, the random number generator generates a mixture of symbols. If the given combination matches the jackpot combination, you win big time.